1. Botanical profile & tariku nafama .
Eucommia ulmoides oliv. Jiri min bɛ bɔ Sinuwa jamana na, o ɲɔgɔn tɛ, a bonyalen don Sinuwaw ka laadala furakɛli la kabini san 2,000+. A buluw bɛ sɔrɔ a buluw la:
3-5% Pinoresinol diglucoside (PDG) .- Marka fɔlɔ min bɛ baara kɛ .
2-3% Asidi genipozidiki .- Glycoside iridoïde kɛrɛnkɛrɛnnen .
1.2% Asidi kulorojeni .- antioxydant synergique .
2. Fito-Kimikɛli matiriyali & waleyali fɛɛrɛ .
2.1 Kolajeni biyosintɛzi sira .
2.2 Bioactives & Targets Key .
|
Dukɛnɛ |
Concentration . |
Molecules ka laɲini . |
Clinical Effect . |
|
Pinoresinol DG . |
3-5% |
MMP-2/9 balili . |
A bɛ senkɔniw tiɲɛni dɔgɔya ni 62% ye . |
|
Asidi genipozidiki . |
2-3% |
ACE balili (IC50=8.2μm) . |
A bɛ BP sistoliki dɔgɔya ni 15-20mmhg ye . |
|
Aucubin . |
0.8-1.2% |
NF-κB sira damatɛmɛni . |
A bɛ dɔ bɔ kolotugudaw funu taamasiɲɛw la . |
3. Jogoɲumanya jateminɛ kɛcogo .
3.1 Lafasali sɛgɛsɛgɛliw .
Macroscopic .: furabuluw ka kan ka lastikuw jira ni u tigɛra ni u tigɛra .
Microscopie .: Oxalate kalisiyɔmu kuluw (20-40μm cɛmancɛ) .
HPLC bolokɔfɛfɛnw .: A ka kan ka 5 jira jogo kuncɛlenw na .
3.2 Modern Standardisation .
EU ka furakɛlicogo .: a bɛ PDG 2,5% ka ca walima a bɛ bɛn o ma .
Japon ka sariyaw .: Lignans bɛɛ lajɛlen ka bon walima ka bɛn 8% ma .
USP .: nɛgɛ gɛlɛnw .<10ppm total
4. Dɔgɔtɔrɔso baarakɛcogo .
4.1 Musculoskeletal dilancogo .
Tenopathie .: miligaramu 500/tile kolajɛ fibre alignment ɲɛnabɔlen dɔgɔkun 8 kɔnɔ (MRI-Labɛn)
Kolotugudaw .: WOMAC ka jatew dɔgɔyara ni 45% ye ni furakisɛ ye .
4.2 Dusukun ni jolisiraw nafa .
Tansiyɔn jiginni .: Banabagatɔ 48% ye normotension sɔrɔ kalo 3 kɔfɛ .
Artériel stiffness .: Pulse wave velocity (pulse wave velocity) bɛ dɔgɔya ni 1,2m/s ye .
5. Baarakɛcogo ɲuman fɛɛrɛ .
5.1 Bioavailability enhancement .
nano-Encapsulation .: A bɛ dɔ fara PDG minɛcogo kan ka bɔ 12% → 89% .
A bɔli waati la .: Sɔgɔmadafuraw bɛ ɲɔgɔn sɔrɔ ni kɔritizɔli ritmɛ ye kolajɛni kɛcogo la .
5.2 Sinsinnanw faralen ɲɔgɔn kan .
Kolajɛ suguya II .: A bɛ extracellular matrix remodeling bonya .
Asidi hyaluronic .: A bɛ jolilabanaw ɲɛ .
Magnesium .: A bɛ fanga di farikolo ma-Tendon lafiya .
6. Lakanali & a kunbɛncogo .
Kɔnɔmaya .: Aw bɛ aw yɛrɛ tanga denso kɔnɔnatumuw lawulili ma .
Antikoagulant baarakɛlaw .: PT/INR (Effect antiplate antile) kɔlɔsibaga .
Bana minnu bɛ sɔrɔ farikolo tangacogo la .: farati teori la farikolo tangacogo la .
7. Suguda danfara .
Premium Products Feature:
Kungo-Buluw dilannen don Sichuan mara la .
CO2 supercritique extraction .
3nan-Party Collagen Stimulation Assays .
Jatɔya faratiw:
Substitution ni duguma-So musaka bɔlenw .
PDG spiking artificiel .
8. Ɲininikalan dancɛw bɛ ka bɔ kɛnɛ kan .
Telomerase baarakɛcogo .: Dalilu fɔlɔw minnu bɛ anti-sɛgɛsɛgɛli nɔw kan .
Biogenesis mitochondriale .: A bɛ PGC-1 kɔrɔta farikolo yɔrɔw la .
Gut-Axis jɛlen .: A bɛ Akkermansia muciniphila jamanadenw .
Kuncɛli
Eucommia Leaf Extract bɛ paradigme shift jira connective tissue support la ni:
1️⃣ Dilancogo minnu bɛ kɛ endojeni kɔnɔ .(VS ka dumuni dafabali) .
2️⃣ Multi-Tissue nafaw .(Tendonw, joli siraw, kolotugudaw)
3️⃣ Waati-Sariyako ɲuman .(2000+ San minnu bɛ kɛ ni sɛbɛnw ye)
Walasa ka ɲɛtaa ɲuman sɔrɔ, aw bɛ fara ɲɔgɔn kan ni .Witamini C (500mg) .Walasa ka kolajeni Cross-Jɛɲɔgɔnya kɛ, ani ka jateminɛ kɛ .San o san kalo 3 kɔnɔ .ka ɲɛsin bana basigilenw ma.
